Incidence of rhabdomyolysis with daptomycin
WebDec 13, 2024 · The incidence of rhabdomyolysis was significantly higher following concomitant daptomycin and statin use than with daptomycin alone (OR = 11.60, 95% CI … WebDaptomycin has been associated with raised creatine kinase activity, with a reported incidence of 2.8% in phase III clinical trials (167 A). Rhabdomyolysis has also been described (168 A ) . A 45-year-old woman with refractory acute myeloid leukemia was given intravenous daptomycin 550 mg (6 mg/kg) every 24 hours because of bacteremia due to ...
Incidence of rhabdomyolysis with daptomycin
Did you know?
WebNov 17, 2024 · However, the risk of developing rhabdomyolysis from statin therapy is very low, around 1.5 for each 100,000 people taking statins. Rhabdomyolysis or milder forms … WebMar 19, 2024 · The meta-analysis found that statin use significantly increased the incidence of DAP-related rhabdomyolysis compared with no statin use (6.2% vs 13.0%; odds ratio [OR] 3.83; 95% CI 1.43, 10.26) but had no significant effect on the incidence of DAP-related myopathy (6.6% vs 6.0%).
WebThere have been reports of myopathy, rhabdomyolysis, and increased creatine phosphokinase (CPK) levels in patients taking daptomycin, which increased when daptomycin was given more than once per day. WebMar 7, 2024 · INTRODUCTION. Daptomycin is a lipopeptide antimicrobial with activity against gram-positive organisms, including antimicrobial-resistant pathogens such as …
WebJun 15, 2006 · Abstract. The use of daptomycin has been associated with an elevation in creatine phosphokinase level, with a reported incidence of 2.8% in phase III clinical trials. … WebRhabdomyolysis is a known possible complication associated with daptomycin therapy. However, previous findings were predominantly in phase 1 and 2 trials, and the effects …
WebFactors conferring increased risk for daptomycin-associated myopathy or rhabdomyolysis include : … Overview of the causes and treatment of hyperphosphatemia … lysis syndrome, muscle necrosis ( rhabdomyolysis ), and, rarely, marked hemolysis or …
WebMar 21, 2024 · Incidence not known Diarrhea, watery, and severe, which may also be bloody dry cough puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue stomach cramps or tenderness Other side effects of Daptomycin Some side effects of daptomycin may occur that usually do not need medical attention. daily gold hornWebJan 16, 2024 · Rhabdomyolysis means dissolution of skeletal muscle, and it is characterized by leakage of muscle cell contents, myoglobin, sarcoplasmic proteins (creatine kinase, lactate dehydrogenase, aldolase, … biohm test reviewsWebThe incidence of myopathy and rhabdomyolysis were highest during the first year and then decreased during the subsequent years of treatment. ... Daptomycin Clinical Impact: Cases of rhabdomyolysis have been reported with simvastatin administered with daptomycin. Both simvastatin and daptomycin can cause myopathy and rhabdomyolysis when given ... biohof braun gbrWebDaptomycin requires prior approval. Baseline CK followed by weekly CK should be measured in patients placed on daptomycin due to increased risk of rhabdomyolysis. Increased dose of daptomycin may be indicated with documented MRSA bacteremia. Infections due to fungi, mycobacteria, or Actinomyces require longer durations of therapy – daily gold prices 2021WebDec 11, 2024 · Daptomycin is associated with an increased incidence of myopathy and rhabdomyolysis. There have been cases reported in patients with and without acute renal … biohof buchholzWebRhabdomyolysis is a well-known clinical syndrome of muscle injury associated with myoglobinuria, electrolyte abnormalities, and often acute kidney injury (AKI). The pathophysiology involves injury to the myocyte membrane and/or altered energy production that results in increased intracellular calcium concentrations and initiation of destructive … daily gold prices for 2020WebDec 4, 2024 · National Center for Biotechnology Information biohof bursch angebote