Ctgf and liver fibrosis
WebJun 13, 2024 · Connective tissue growth factor (CTGF, also known as CCN2), a member of the CCN family of matricellular proteins, is widely known as a hallmark of fibrosis in multiple tissues, including skin, heart, lung, liver, and kidney [ 3, 4 ]. WebOct 3, 2024 · Organ fibrosis often ends in eventual organ failure and leads to high mortality. Although researchers have identified many effector cells and molecular pathways, there …
Ctgf and liver fibrosis
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WebSep 1, 2006 · Results: The mean concentration of CTGF was highest in the fibrosis group (5.2-fold) and in the chronic viral hepatitis group (4.3-fold) but lower in those patients with fully developed cirrhosis. The area under the ROC curve (AUC) of CTGF for fibrosis vs control was 0.955 (95% confidence interval, 0.890–0.987). WebAug 6, 2024 · Background: Glomerulonephritis, which causes inflammation in glomeruli, is a common cause of end-stage renal failure. Severe and prolonged inflammation can …
WebJun 6, 2012 · For example, in liver fibrosis models CTGF is known to increase in response to toxins such as CCl 4 or dimethyl nitrosamine or upon bile duct … WebMay 8, 2024 · Connective tissue growth factor (CTGF) associated with transforming growth factor-β (TGF-β) play a pivotal role in the pathophysiology of many fibrotic disorders. …
WebNov 1, 2024 · Paracrine factors such as platelet-derived growth factor (PDGF), transforming growth factor β (TGFβ), and connective tissue growth factor (CTGF), together with other growth factors and cytokines/chemokines, activate cellular signaling pathways of cell proliferation, migration, ECM protein secretion, and contractility that promote … WebBackground: Connective tissue growth factor (CTGF) belongs to a family of factors that regulate fibrogenesis and wound healing. While the significance of transforming …
WebMay 2, 2006 · The CTGF siRNA treatment markedly reduced serum procollagen type III, hepatic hydroxyproline and liver fibrosis staging. Conclusions. Silencing CTGF expression with siRNA demonstrates therapeutic potential to prevent liver fibrosis by inhibiting HSC activation with consequent extracellular matrix accumulation and the upregulation of TGF …
WebApr 11, 2024 · During chronic hepatitis B virus (HBV) infection, hepatic fibrosis is a serious pathological condition caused by virus-induced liver damage. The activation of hepatic stellate cells (HSCs) is a central event in the occurrence and progression of liver … green tea and ocdWebJun 5, 2024 · Therefore, NNMT, in conjunction with a NAM-rich diet, aggravates liver fibrosis, at least in part, through epigenetic changes to CTGF. Body weight and adiposity decreased in Tg mice fed an HFD ... green tea and metabolism weight lossWebJan 8, 2024 · Carbon tetrachloride (CCl4) is widely used to induce hepatic fibrosis. Therapeutic agents alleviate hepatic fibrosis by inhibiting signal transducer and activator … green tea and olive oil for hairWebHepatic fibrosis, which has characteristics of excessive deposition of extra cellular matrix (ECM), occurs by various chronic liver injuries, such as from chemicals, viral infection, … green tea and osteoarthritisWebMar 20, 2024 · Liver fibrosis (LF) is caused by chronic liver injury from various causes, such as viral infections, alcohol consumption, non-alcoholic fatty liver disease (NAFLD), cholestatic liver disease, and autoimmune hepatitis. ... resulting in the inhibition of CTGF and its downstream targets . green tea and orangeWebApr 8, 2024 · Multiple studies illustrate the abilities of neutralizing anti-TGF-β antibodies and TGF-β receptor kinase inhibitors to prevent fibrosis in preclinical models of lung, liver, … green tea and oral cancerWebOct 3, 2024 · Organ fibrosis often ends in eventual organ failure and leads to high mortality. Although researchers have identified many effector cells and molecular pathways, there are few effective therapies for fibrosis to date and the underlying mechanism needs to be examined and defined further. Epoxyeicosatrienoic acids (EETs) are endogenous lipid … fnaf ultimate custom night all death lines