Cisplatin pten

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August undefined, 2024

WebSpiral ganglion neurons (SGNs) are auditory neurons that relay sound signals from the inner ear to the brainstem. The ototoxic drug cisplatin can damage SGNs and thus lead to sensorineural hearing loss (SNHL), and there are currently no methods for preventing or … WebApr 10, 2024 · Indeed, PTEN serves as a dual-specific phosphatase that suppresses cell proliferation and induces apoptosis and cell cycle arrest via repressing PI3K/Akt signaling mechanisms [208]. Zheng et al. revealed that miR-24 increases the chemoresistance of human TSCC cell lines to cisplatin by downregulating PTEN [209].

The renoprotective effect of curcumin against cisplatin-induced …

WebBackground: Platinum-based chemotherapy, cisplatin (DDP) specifically, is the main strategy for treating lung cancer (LC). However, currently, there is a lack of predictive drug-resistance markers, and there is increased interest in the development of a reliable and sensitive panels of markers for DDP chemotherapy-effectiveness prediction. MicroRNAs … WebSep 28, 2007 · We report that EF24, a synthetic compound 3,5-bis (2-flurobenzylidene)piperidin-4-one, greatly inhibits cisplatin-resistant (CR) human ovarian cancer cell proliferation. The inhibitory effect of EF24 on cell proliferation is associated with G (2)/M phase cell cycle arrest and increased G (2)/M checkpoint protein (pp53, p53, … curtain bangs fails

Cisplatin (Cisplatin Injection): Uses, Dosage, Side

WebCisplatin / pharmacology Cyclin-Dependent Kinase Inhibitor p27 / metabolism Drug Synergism Female Gene Expression Regulation, Neoplastic / drug effects Humans Intracellular Signaling Peptides and Proteins / antagonists & inhibitors Intracellular Signaling Peptides and Proteins / genetics* Intracellular Signaling Peptides and Proteins / … WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often … WebSep 24, 2024 · The main lipid substrate of PTEN is PIP 3 and indeed PTEN acts as a negative regulator of PI3K/AKT signaling. ... Wu, D. M. et al. The PAX6-ZEB2 axis promotes metastasis and cisplatin resistance ... chase bank centennial colorado springs

IJMS Free Full-Text MicroRNAs as Predictors of Lung-Cancer ...

WebApr 13, 2024 · HIGHLIGHTS who: Florentine S. B. Subtil et al. from the Department of Radiotherapy and Radiooncology, Philipps-University, Marburg, Germany have published the research: Dual PI3K/mTOR Inhibitor NVP-BEZ235 Leads to a Synergistic … Dual pi3k/mtor inhibitor nvp-bez235 leads to a synergistic enhancement of cisplatin and … WebThis is the case of vesicular miR-21 that induced cisplatin resistance in oral squamous cell carcinoma by targeting phosphatase and tensin homolog (PTEN) and programmed cell death protein 4 (PDCD4), which are tumor suppressors involved in apoptosis, cell transformation, invasion, and tumor progression . curtain bangs filter onlineWebJan 12, 2024 · Cervical cancer is one of the most common female malignancies, and cisplatin-based chemotherapy is routinely utilized in locally advanced cervical cancer patients. However, resistance has been the major limitation. In this study, we found that Na+/H+ Exchanger Regulatory Factor 1 (NHERF1) was downregulated in cisplatin … chase bank central louisiana

"WebCisplatin inhibited Akt phosphorylation and activation in OVCAR-3 cells but not in OVCAR-3/CDDP cells. The specific PI3K inhibitors LY294002 and wortmannin sensitized OVCAR-3/CDDP cells to cisplatin-induced apoptosis and decreased cell viability. " - Cisplatin pten

Cisplatin pten

WebApr 25, 2024 · In this study, we investigate the role of miRs and PTEN in renoprotective effect of curcumin against cisplatin-induced AKI in mice. It is aimed to reveal the mechanism of curcumin which protected the kidney and provided evidence on the therapeutic application of curcumin in alleviating AKI. Go to: Materials and methods Drugs WebApr 5, 2013 · In addition, miR-21 induced cell survival and cisplatin resistance through downregulating the expression of phosphatase and tension homolog deleted on chromosome 10 (PTEN) and activation of Akt pathway. Inhibition of Akt using PI3K inhibitor LY 294002 could abrogate miR-21 induced cell survival.

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WebPTEN is a tumor-suppressor gene deactivating PI3K downstream of EGFR signaling. We hypothesize that PTEN-deficient lung cancer cells suppressed DNA damage signaling and that the absence of PTEN can sensitize these cells to a concurrent treatment of a DNA-damaging agent (cisplatin) and a PARP inhibitor (olaparib). WebJul 15, 2024 · Currently; cisplatin has been widely used to treat solid tumors including lung cancer ( Dasari and Tchounwou, 2014, Galluzzi, 2012 ). However, many patients acquire …

WebNov 21, 2024 · PTEN-induced putative kinase 1 (PINK1)/Parkin-mediated mitophagy removes damaged mitochondria under various pathological conditions. The objective of this study was to determine mitophagy status and its effects on mitochondrial function and neuronal cell damage after cisplatin treatment using an in vitro model of cisplatin … WebFeb 16, 2024 · Generic name: cisplatin [ sis-PLA-tin ] Brand names: Platinol, Platinol-AQ, Platinol (Restricted Access) Dosage forms: intravenous powder for injection (50 mg), …

WebConclusion: TGF-β induced TMEPAI contributes to the reduced response of TNBC treatment to doxorubicin and paclitaxel, but minimal on cisplatin and bicalutamide. Further study is needed to confirm our findings in other growth factor-induced cells, as well as in in vivo model. Keywords: TMEPAI, TGF-β, doxorubicin, paclitaxel. WebMay 10, 2013 · Cisplatin treatment promotes phosphorylation of AKT. PTEN is known as a negative regulator of AKT phosphorylation. The phosphorylation of AKT was analyzed …

WebJun 7, 2024 · The PTEN gene was hypothesized to be regulated by miRNA-21 in ovarian cancer cisplatin resistance. Materials and methods Cell lines and cell culture The SKOV3 human ovarian cancer cell line was purchased from Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (Shanghai, China).

WebNov 19, 2024 · Cisplatin is an anti-cancer chemotherapy drug which used to treat ovarian cancer in women who have already received surgery and/or radiation treatment. However, either resistance to cisplatin or multi-drug resistance (MDR) to cisplatin-centered chemotherapy is a major cause of treatment failure in human ovarian cancer. chase bank central aveWebDec 14, 2015 · Cisplatin is a first-line chemotherapeutic agent for ovarian cancer that acts by promoting DNA cross links and adduct. However drug resistance and considerable side effects including reproductive toxicity remain a significant challenge. PTEN is well known as a tumor suppressor function which plays a fundamental role in the regulation of the cell … chase bank centre ave portage miWebSep 24, 2024 · Cisplatin (CDDP) is the drug of choice against different types of cancer. However, tumor cells can acquire resistance to the damage caused by cisplatin, generating genetic and epigenetic changes that lead to the generation of resistance and the activation of intrinsic resistance mechanisms in cancer cells. Among them, we can find mutations, … curtain bangs for 10 year oldsWebMay 17, 2024 · Cisplatin is a bifunctional platinum (II) complex with two chloride leaving ligands. The monofunctional platinum (II) complex, phenanthriplatin, has one chloride leaving ligand, and steric bulk... curtain bangs fluffy hairWebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … chase bank century center modestoWebObjective: Resistance to cisplatin-centered chemotherapy is a major cause of treatment failure in human ovarian cancer. Whereas PTEN, a tumor suppressor gene product, is believed to promote apoptosis primarily via inactivation of the PI3K/Akt cell survival pathway, recent evidence suggests that PTEN may function independently of this pathway. chase bank ceoWebSep 8, 2024 · Cisplatin (cis-Diamminedichloroplatinum II) has been widely and effectively used in chemotherapy against tumors. Nephrotoxicity due to cisplatin is one of the most … chase bank centre street portage mi